As spotted on the official forums, GI Editor-in-Chief Andy McNamara has repsonded to a query about next months cover, "I'm going to guess the next @gameinformer cover will be for Hitman 5. What do you say, @GI_AndyMc?" with:
Not a bad guess, but sadly... no. It is however a sequel and a highly anticipated one at that!"Obviously incredibly vague, and could be anything, but it is an enticing thought. Although, I am slightly disappointed it won't be Hitman 5, since I love those games.
Other possibilities, BioShock Infinite, Battlefield 3, Tomb Raider, Skyrim, Infamous 2, Saint's Row 3, Arkham City, Resistance 3 and Gears of War 3 have all had recent GI covers anyway and there's plenty of information out about them already. That leaves Mass Effect 3, The Last Guardian and Call of Duty: MW3 as the only remaining, biggest, low-info, 2011, sequels that are highly anticipated that I can think of.
DA2 was also revealed in GameInformer, so it's not something BioWare or EA are averse to doing, and the timing sure seems right. Most other holiday 2011 games (Uncharted 3, Skyrim etc.) have all had much more info about them revealed.