You automatically acquire this mission after completing Priority: Rannoch.
The asari councilor will contact Shepard on the vid-com immediately upon return to the Normandy, telling them that she has vital information that must be shared in person.
To begin the mission, travel back to the Citadel. Once you have arrived, travel to the Citadel Embassies and make your way to the late Councilor Udina's office. Enter to trigger a cutscene. The asari Councilor will tell you that the Asari Republic has taken a turn for the worst, and will proceed to tell you that a Prothean artifact is hidden in the Temple of Athame on the asari homeworld, Thessia. Once you have been dismissed, the mission will end and you will acquire the mission Priority: Thessia.Urdnot Wrex leads the krogan, he will be waiting for you at Normandy Dock: Bay D24 with a recording of your conversation with Dalatrass Linron. Enraged at this betrayal, he tries to kill Shepard. He cannot be reasoned with regardless of your choice of words.
There are two Renegade interrupts that will allow you to shoot him, but in both cases Bailey and C-Sec will take him down if you decline.
Bypassing Wrex Edit
Because Mass Effect 3: Leviathan added rapid transport terminals throughout the Citadel, it is now possible to sabotage the cure, obtain salarian support and keep Wrex alive until the end of the game. This was probably an unintended consequence of using them since story sequence breaks in at least one other scenario: choosing whether the Virmire survivor stays with you or goes with Hackett.
The drawback is that you'll never be able to return to the Citadel all the way to the point the Reapers commandeer the station after Priority: Cerberus Headquarters for fetch quests or whatever business you might have there but this can be mitigated by careful mission planning and execution.
- You sabotaged the genophage cure, killed the salarian scientist in the way and Wrex is the krogan leader. proceed normally.
- You've just finished Priority: Rannoch. Do every Search and Rescue operation and any other mission available up to this point if you want.
- Go meet the asari councilor for Priority: The Citadel III, this mission. Complete every mission on the Citadel as the opportunities to do so are very limited if you don't want Wrex to die.
- Have a Bryson's Lab Leviathan mission available. Instead of taking the rapid transport to the Normandy or going back there through the Docking Bay (in which Wrex will appear out of nowhere to get killed) do that mission instead and at its conclusion head straight back to the Normandy. You will bypass the entire encounter with Wrex on the Docking Bay and this is potentially repeatable so long as you have a Bryson's Lab mission (there's three: Citadel: Leviathan I, Citadel: Leviathan II, and Citadel: Leviathan III).
- You can return to the Citadel up until before Priority: Cerberus Headquarters where the Citadel becomes unavailable afterwards. Just make sure to have enough Bryson's Lab missions available to keep the confrontation from happening. Expect to see Wrex in the ruins of London as if he, like his brother Wreav, never realized the cure was fake.
Priority: Thessia becomes available. If the cure of the genophage is sabotaged and Wrex leads, you also lose the Clan Urdnot and krogan mercenaries War Assets. (If Urdnot Wreav leads, he remains oblivious through the end of the game.)
Additionally, the incident with Wrex appears to have been covered up as evidenced by this mail you'll receive on the Normandy if you were forced to kill him.
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