If Shepard has sniper rifle training, then bringing along squadmates who are similarly trained may prove useful. You'll be facing enemies who are quite difficult to damage, so Shredder Ammo and Warp can increase your damage potential.
If you're not sniper trained and still planning to fight enemies on foot for higher XP rewards than the Mako's cannon offers, Damping can prevent enemies from using their Immunity ability, and Neural Shock will drop them immediately to the ground where they can be quickly blasted with Carnage or otherwise pumped full of holes. Biotics will keep pirates off their feet, which helps reduce the amount of incoming fire but will lead to having to chase them around.
Walkthrough EditAgebinium. Land on the surface, and make your way to the mine (labeled "Alliance Homing Beacon" on the map). When you reach the probe in the back of the mine you'll trigger a trap set by Elanos Haliat, the mastermind behind the Skyllian Blitz. If Shepard has the War Hero background, Haliat will claim that he is having his revenge for Shepard's responsibility in repelling the Blitz (and Haliat's subsequent loss of reputation among his band of pirates when the attack failed), and sets the nuclear device on the probe to overload in order to kill Shepard. With either of the other two backgrounds, Haliat will still set off the bomb as a form of general revenge against the Alliance and because his operation had been discovered. You now have ten seconds before the bomb goes off to disable it.
Disabling the bomb entails disarming three hard points on the probe, each involving a mini-game or omni-gel, at 100 units each. These mini-games have a much longer sequence than most others, and thankfully progress more slowly. Once you've disabled the bomb, you'll discover that the way you came in is now blocked by fallen debris. The other airlock door, which was previously inaccessible, is now interactive and can be opened. Make sure to grab the upgrade kit right inside the door before you escape the mine and return to the surface. Your antagonist is just over the next rise with your Mako and some assorted criminals. Take out Haliat and his goons to end the assignment.sniper rifle, it is easier to snipe them one by one from above. Otherwise, run down the slope and quickly get in the Mako - if you haven't fired at the enemies they will not alert in time to do significant damage. Use the Mako's big cannon to clear the area and end the assignment - though since these pirates have armor that can miraculously survive a direct hit from the cannon, expect to be chasing a few all the way up the hillside or into the next valley over. If you can eliminate the enemy snipers, getting back out of the Mako and fighting the rest of the pirates on foot for higher XP rewards also becomes a reasonable option.
Another way to get the Mako is to teleport back to the Normandy from the Map section of the squad menu, from whence you can go back with the Mako and finish off Haliat's gang.