Your lvl shows, that this is your 2nd or 3rd playthrough, right? What skills did you max? a favourite weapon? Who survived Virmire? Do you want to transfer your save to ME2?
The easiest way imo is to equip yourself and your squad with the colossus X armor, because damage reduction is far more effective than a larger shield on insanity. Combined with immunity you can take a lot of damage before you get into serious trouble.
Did you save some tungsten VII and shredder VII rounds? They are the best ammo regarding max damage. Best choice without changing the ammo is incendiary X or sledgehammer to stop enemy health regeneration.
Easiest way.... Maxed out Skill (Overkill or Marksman) and Spectre X Assault Rifle or Pistol.
Companions: I guess money is no problem after 1 playthrough, i never had one... so pick 2 with biotics, because shields won't stop them. Especially warp is damn good, because your foes use immunity almost all the time and warp nearly eliminates the effect of immunity..... and Saren is quite susceptible to biotics like lift, just as a geth colossus.
tl:dr Colossus Armor, Spectre X Assault Rifle, Biotic Squadmates with maxed Lift and or Warp.