I started it (my first time too) but haven't got very far yet. My hubby is an avid ME player and warned me to get my rep up with companions asap but I can't remember off the top of my head why. He's not home or I would ask. What I have played so far has been fun.
By all means enjoy it! And remember to talk to your companions and get access to their loyalty missions, then complete them appropriately! The only one I had any issue with was Thane's my first time...easy enough though with the wiki. Doing side quests like these may seem tedious but it's story immersion, opens the door to some potential romances, and most importantly gains their loyalty which is invaluable in the final mission! Also intelligent decision making. But really just using common sense and gaining your followers' trust will ensure a success so enjoy the game it's been years since my first playthrough of ME2 I envy you. The first time is always the most intense.